Dessie is located along Ethiopian Highway 1. It has postal service (a post office was established in the 1920s), and telephone service from at least as early as 1954. The city has had electrical power since at least 1963 when a new diesel-powered electric power station with a power line to Kombolcha was completed, at a cost of Eth$ 110,000. Intercity bus service is provided by the Selam Bus Line Share Company. Dessie shares Combolcha Airport (ICAO code HADC, IATA DSE) with neighbouring Kombolcha.
Dessie is home to a museum, in the former home of Dejazmach Yoseph Birru. It also has a zawiya of the Qadiriyya order of Islam, which was the first Sufi order to be introduced into north-east Africa.
Colneleate synthase (EC18.104.22.168, 9-divinyl ether synthase, 9-DES, CYP74D, CYP74D1, CYP74 cytochrome P-450, DES1) is an enzyme with system name (8E)-9-((1E,3E)-nona-1,3-dien-1-yloxy)non-8-enoate synthase. This enzyme catalyses the following chemical reaction